منابع مشابه
Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.
N-Deacetylase-N-sulfotransferase 1 (Ndst1) catalyzes the initial modification of heparan sulfate and heparin during their biosynthesis by removal of acetyl groups from subsets of N-acetylglucosamine units and subsequent sulfation of the resulting free amino groups. In this study, we used a phage display library to select peptides that interact with Ndst1, with the aim of finding inhibitors of t...
متن کاملN-Benzylpyridin-2-amine
In the crystal of the title compound, C(12)H(12)N(2), inter-molecular N-H⋯N hydrogen bonds form rings of graph-set motif R(2) (2)(8) and C-H⋯π inter-actions further consolidate the dimers. Neighbouring dimers are further connected into a three-dimensional network by C-H⋯π inter-actions. The benzyl and pyridyl rings form a dihedral angle of 67.2 (1)°
متن کاملHeparan sulfate/heparin N-deacetylase/N-sulfotransferase. The N-sulfotransferase activity domain is at the carboxyl half of the holoenzyme.
Glycosaminoglycan N-acetylglucosaminyl N-deacetylases/N-sulfotransferases are structurally related enzymes that play an important role in the biosynthesis of heparan sulfate and heparin. They are dual catalytic, single membrane-spanning polypeptides of approximately 850-880 amino acids that catalyze the N-deacetylation of N-acetylglucosamine of glycosaminoglycans followed by N-sulfation of the ...
متن کاملN,N′-(4-Chlorobenzylidene)dipyrimidin-2-amine
The title compound, C(15)H(13)ClN(6), contains two pyrimidine rings and one benzene ring, where the dihedral angle between the planes through the pyrimidine rings is 81.57 (10)°, and those between the pyrimidine rings and the benzene ring are 84.02 (8) and 89.46 (7)°, indicating that the three rings are almost perpendicular. In the crystal, inter-molecular N-H⋯N hydrogen bonds link the mol-ecul...
متن کاملN-(Ferrocenylmethyl)dodecan-1-amine
The title compound, [Fe(C(5)H(5))(C(18)H(32)N)], was synthesized by the amination of ferrocenecarbaldehyde. In the complex, the two cyclo-penta-dienyl (Cp) rings are almost parallel with a dihedral angle of 1.36 (8)°, and are separated by a centroid-centroid distance of 3.299 (2) Å. In the crystal, adjacent mol-ecules are linked into a one-dimensional supra-molecular structure via weak C-H⋯π in...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1987
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)61071-3